Search on: COMPLEMENT C3B 
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Descriptor English:   Complement C3b 
Descriptor Spanish:   Complemento C3b 
Descriptor Portuguese:   Complemento C3b 
Tree Number:   D12.776.124.486.274.250.260
Definition English:   The larger fragment generated from the cleavage of COMPLEMENT C3 by C3 CONVERTASE. It is a constituent of the ALTERNATIVE PATHWAY C3 CONVERTASE (C3bBb), and COMPLEMENT C5 CONVERTASES in both the classical (C4b2a3b) and the alternative (C3bBb3b) pathway. C3b participates in IMMUNE ADHERENCE REACTION and enhances PHAGOCYTOSIS. It can be inactivated (iC3b) or cleaved by various proteases to yield fragments such as COMPLEMENT C3C; COMPLEMENT C3D; C3e; C3f; and C3g. 
Indexing Annotation English:   /antag: consider COMPLEMENT C3B INACTIVATOR PROTEINS
Pharmacological Action:   Immunologic Factors
 
See Related English:   Receptors, Complement 3b
 
History Note English:   2006 (1978) 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AG agonists AN analysis
AI antagonists & inhibitors BI biosynthesis
CF cerebrospinal fluid CS chemical synthesis
CH chemistry CL classification
CT contraindications DF deficiency
DE drug effects EC economics
GE genetics HI history
IM immunology IP isolation & purification
ME metabolism PK pharmacokinetics
PD pharmacology PH physiology
PO poisoning RE radiation effects
SE secretion ST standards
SD supply & distribution TU therapeutic use
TO toxicity UL ultrastructure
UR urine  
Record Number:   22315 
Unique Identifier:   D003179 

Occurrence in VHL: 		 

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